UNDERLYING MECHANISM OF CKD

When CKD is left unchecked, kidney function continues to decline.2,14 Here’s why.

CKD Kidney Overlay

Inside the kidneys,
pressure is building

While patients may experience no early symptoms of CKD, inside their kidneys, intraglomerular pressure is building.2,14

As intraglomerular pressure builds, it slowly destroys nephrons, leading to progressive damage and reduced kidney function.2,3,14

Intraglomerular pressure in the kidney
Intraglomerular pressure in the kidney

INSIDE THE KIDNEYS,
PRESSURE IS BUILDING

Inside kidneyInside kidneyLOOK INSIDE

INSIDE THE KIDNEYS,
PRESSURE IS BUILDING

CKD Kidney Overlay

Inside the kidneys,
pressure is building

While patients may experience no early symptoms of CKD, inside their kidneys, intraglomerular pressure is building.2,14

As intraglomerular pressure builds, it slowly destroys nephrons, leading to progressive damage and reduced kidney function.2,3,14

CKD, chronic kidney disease; CV, cardiovascular; eGFR, estimated glomerular filtration rate; GFR, glomerular filtration rate.

References

  1. Ryan TP et al. Am J Med. 2007;120(11):981–986.
  2. Ravera M et al. Am J Kidney Dis. 2011;57(1):71–77.
  3. GBD Chronic Kidney Disease Collaboration, Lancet. 2020;395(10225):709–733.
  4. Alabama Department of Public Health. Special Task Force on Chronic Kidney Disease report. April 2007. Accessed 20 November 2020.
    https://www.alabamapublichealth.gov/publications/assets/kidneydiseasereport.pdf
  5. Kidney Disease: The Basics. National Kidney Foundation. Published May 2020. Accessed 20 November 2020.
    https://www.kidney.org/news/newsroom/factsheets/KidneyDiseaseBasics
  6. Brenner BM et al. N Engl J Med. 2001;345(12):861–869.
  7. Go AS et al. N Engl J Med. 2004;351(13):1296–1305.
  8. Estimated glomerular filtration rate (eGFR). National Kidney Foundation. Reviewed 14 September 2020. Accessed 25 November 2020.
    https://www.kidney.org/atoz/content/gfr
  9. Ghaderian SB et al. J Renal Inj Prev. 2014;3(4):109–110.
  10. Courser WG et al. Kidney Int. 2011;80(12):1258–1270.
  11. Chronic kidney disease basics. Centers for Disease Control and Prevention. Page reviewed 7 February 2020. Accessed 6 October 2020.
    https://www.cdc.gov/kidneydisease/basics.html
  12. Kidney Disease Stats. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. December 2016. Accessed 25 November 2020.
    https://www.niddk.nih.gov/health-information/health-statistics/kidney-disease
  13. Yacoub R, Habib H, Lahdo A, et al. Association between smoking and chronic kidney disease: A case control study. BMC Public Health. 2010;10:731.
  14. Schnaper HW. Pediatr Nephrol. 2014;29(2):193–202.